OMTE MLX
Maturation and transfer of MONOLIX software, a modelling tool for pharmacometrics and in particular PK-PD (pharmacokinetics-pharmacodynamics)
The INRIA (in collaboration with CNRS, Université Paris-Sud 11 and INSERM) is developing the MONOLIX modelling software used in pharmacometrics*, which is highly effective, flexible and user-friendly.
The software uses the most powerful stochastic algorithms, both in terms of speed, quality of results and range of models it can process. It also possesses a graphic interface which is very popular with users.
MONOLIX is therefore positioning itself as the leading tool for population pharmacology modelling.
*"Pharmacometrics" is a recently developed discipline which aims to provide better analysis of the range of physiological data (concentrations, biomarkers, pharmacological effects, undesirable effects) as well as their development over time and their variability between patients.
It aims to achieve a better understanding of the whole dose-response relationship in order to help plan clinical trials, especially through simulation, by taking better account of sources of variability and uncertainty. These analyses rely on more or less simple physiological models and require more complex statistical tools such as non-linear mixed effects modelling.
